UroToday- Hypogonadal men often seek testosterone replacement therapy. To eliminate the chance that they harbor prostate cancer (CaP), it is considered prudent to check the PSA level and biopsy them if elevated. However, in the December 2006 issue of Urology, Drs. Morgentaler and Rhoden report that CaP is present in more than 1 of 7 hypogonadal men with a PSA of 4.0ng/ml or less.

Their study cohort consisted of 345 men diagnosed with hypogonadism prior to initiating testosterone replacement therapy. All men had low levels of total testosterone (TT) or free testosterone (FT), or both and a PSA level

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